Gypenosides ameliorate ductular reaction and liver fibrosis via inhibition of hedgehog signaling.
Hu Y, He X, Zhou X, Liang Y, Fu Y, Zhang L, Fang J, Liu W, Chen G, Mu Y, Zhang H, Cai H, Liu C, Liu P, Chen J.
Hu Y, et al.
Front Pharmacol. 2022 Nov 22;13:1033103. doi: 10.3389/fphar.2022.1033103. eCollection 2022.
Front Pharmacol. 2022.
PMID: 36483737
Free PMC article.
Results: Both in CCl(4)/2-AAF-treated rats and Mdr2 (-/-) mice, GPs obviously reduced the deposition of collagen and hydroxyproline content, inhibited the activation of hepatic stellate cells and inflammatory cell infiltration. Notably, GPs reduced the expressions of Epcam, CK19, …
Results: Both in CCl(4)/2-AAF-treated rats and Mdr2 (-/-) mice, GPs obviously reduced the deposition of collagen and hydroxyproline content, …